The authors report no relevant financial disclosures.
According to published results, tranexamic acid did not influence pump pressure or improve arthroscopic visualization in patients undergoing rotator cuff repair.
In a prospective, randomized, double-blinded trial, Thema A. Nicholson, MS, and colleagues analyzed 50 patients who received 1 g of IV tranexamic acid (TXA) and 50 patients who did not receive TXA prior to arthroscopic rotator cuff repair for full-thickness tears. According to the study, outcome measures included blood pressure, change in pump pressure, amount of irrigation fluid utilized, visualization (measured by VAS scores), anesthesia interventions for blood pressure and total operative time.
Overall, researchers found “no significant differences” between the groups for any measure of pump pressure. In the TXA group, final arthroscopic fluid pump pressure was 44.5 mmHg; mean change in pump pressure was 20.9 mmHg; and a change in pump pressure was required 1.68 times. In the control group, final arthroscopic fluid pump pressure was 42 mmHg; mean change in pump pressure was 21.8 mmHg; and a change in pump pressure was required 1.74 times. Researchers also found no differences in surgeon visualization, as visualization was 7.42 in the control group and 7.19 in the TXA group.
“Intravenous administration of TXA prior to arthroscopic rotator cuff repair did not influence pump pressure parameters or improve arthroscopic visual clarity in this randomized controlled trial,” Nicholson and colleagues wrote in the study. “Further study with a greater number of surgeons and institutions is needed to confirm these findings,” they concluded.